In the face of Japanese aggression, Liu Manqing acted bravely in the overall interests of the whole country and actively engaged in the anti-Japanese struggle for national salvation. She initiated the establishment of the Tibetan anti-Japanese organization, personally led a team to Xikang and Tibet to undertake propaganda and consolidation work, and mobilized Tibetan people from all walks of life to support and participate in the war of resistance. The Tibetan people donated money and materials to support the war effort.

In 1931, the September 18 Incident occurred in Shenyang, at the hands of Imperial Japan, shocking the country and the whole world. People across the country condemned the Japanese atrocities and demanded that the National Government fight against Japanese aggression.

In November 1931, Liu Manqing attended the Fourth National Congress of Kuomintang, during which, together with other Tibetan representatives, including Lobsang Gyaltsen, Lobsang Angjia, Konchok Jungne, and Ngawang Gyaltsen, she urged the National Government to mobilize the army to fight the Japanese.She stated that she herself would join the fight against Japan for the salvation of the country.